Losing Weight With The Meal That Never Was
Forget appetite suppression and wild snake oil claims. Weight loss pills are successful when they work with the body's normal processes.Don LaVange, CC BY-SA 2.0
A new pill developed by the Salk Institute may be an answer to the giant, out-of-shape question mark that is the American obesity epidemic. Researchers are calling it the “Invisible Meal” because of how it interacts with the body’s digestive system, and if it works as well in humans as it already has in mice, the future of weight loss could see serious turnarounds.
Recently published in an issue of Nature Medicine, the findings hinge on a receptor nestled in much of the body’s gut, called the farensoid X receptor, or FXR. It turns on when we begin to eat food, helping bile to digest the contents for nutrient absorption. But where previous weight loss pills have failed, due to harmful scattershot FXR targeting or other means, such as outright appetite suppression, researchers believe the new pill’s mechanism avoids these risks.
"This pill is like an imaginary meal," said Ronald Evans, director of Salk's Gene Expression Laboratory and senior author of the new paper, in a statement. "It sends out the same signals that normally happen when you eat a lot of food, so the body starts clearing out space to store it. But there
The pill isn’t for people with just a little extra around the waist, however. It’s intended for the some 29.1 million people who suffer from diabetes, many of whom make up the 78.6 million people, or one-third of the population, who is currently obese. If scientists can perfect the pill’s effectiveness while minimizing side effects, they hope it can someday replace gastric bypass surgery as a desired means of major weight loss.
Unlike other FXR-targeting drugs, or others of a different kind altogether, the new pill simulates eating an “invisible meal” just in the intestines, not the entire bloodstream. This narrowed focus allows the intestines to receive the full brunt of the pill’s effects, without any hazardous collateral damage incurred by other organs or causing the person to gain weight.
In future trials, Evans and the team hope to transition the findings from mouse to human models. And to allay any remaining naysayers, the pill wouldn’t be a silver bullet for obesity and diabetes; patients would still need to maintain a healthy balance of diet and exercise — something that hopefully will only get easier as the pounds come off.
Source: Fang S, Suh J, Reilly S, et al. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nature Medicine. 2015.
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